Document Detail


Pharmacokinetics of oral ranitidine in Mexicans.
MedLine Citation:
PMID:  8854394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac, Glaxo de México, Mexico City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitidine plasma concentration increased with time, reaching a maximum of (mean +/- SEM) 484 +/- 34 ng/ml in 2.7 +/- 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 +/- 0.3 h. The area under the plasma concentration against time curve was 2440 +/- 126 ngh/ml. Oral ranitidine pharmacokinetic parameters in Mexicans appeared to be similar to those previously reported for Caucasians.
Authors:
G Castañeda-Hernández; F J Flores-Murrieta; V Granados-Soto; A Herrera-Abarca; J Pérez-Urizar; J E Herrera; E Hong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of medical research     Volume:  27     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-26     Completed Date:  1996-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  MEXICO    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Affiliation:
Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, México, D.F.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Chromatography, High Pressure Liquid
Ethnic Groups
Half-Life
Humans
Male
Mexico
Ranitidine / administration & dosage,  blood,  pharmacokinetics*
Tablets
Chemical
Reg. No./Substance:
0/Tablets; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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