| Pharmacokinetics of nicotine, cotinine, and 3'-hydroxycotinine in cigarette smokers. | |
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MedLine Citation:
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PMID: 3184779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The trans-isomer of 3'-hydroxycotinine has recently been identified as a major metabolite of nicotine in urine of cigarette smokers. We, therefore, investigated the pharmacokinetics of 3'-hydroxycotinine in six male smokers after intravenous infusion of nicotine, cotinine, and 3'-hydroxycotinine. Serum concentrations of 3'-hydroxycotinine were lower than those of cotinine throughout the observation period of 60 h after infusion of nicotine or cotinine, whereas the amounts excreted in the urine were similar or higher than those of cotinine. The following means and ranges for the pharmacokinetic parameters were derived from the 3'-hydroxycotinine infusion experiment: half-life (t1/2 beta) = 5.9 (4.2-9.5) h; apparent volume of distribution (Vd) = 0.87 (0.51-1.14) l/kg; total clearance (Cl total) = 1.79 (1.08-2.59) ml/min/kg; renal clearance (Clr) = 1.31 (0.85-1.78) ml/min/kg; percentage of renal clearance (Clr/Cl total) = 75.4 +/- 12.8 (60.3-98.2). The high percentage of renal clearance suggests that further metabolization of this compound is limited. No evidence for a mutagenic activity of 3'-hydroxycotinine or of urine extracts from subjects dosed with hydroxycotinine was found with the S. typhimurium (TA 98) microsome assay. |
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Authors:
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G Scherer; L Jarczyk; W D Heller; A Biber; G B Neurath; F Adlkofer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Klinische Wochenschrift Volume: 66 Suppl 11 ISSN: 0023-2173 ISO Abbreviation: Klin. Wochenschr. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985205R Medline TA: Klin Wochenschr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 5-11 Citation Subset: IM |
Affiliation:
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Forschungsgesellschaft Rauchen und Gesundheit mbH, Hamburg. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cotinine / administration & dosage, analogs & derivatives, pharmacokinetics* Humans Infusions, Intravenous Male Metabolic Clearance Rate Mutagenicity Tests Nicotine / administration & dosage, pharmacokinetics* Pyrrolidinones / pharmacokinetics* Smoking / blood* |
| Chemical | |
Reg. No./Substance:
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0/Pyrrolidinones; 27323-64-4/hydroxycotinine; 486-56-6/Cotinine; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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