| Pharmacokinetics of nevirapine in human immunodeficiency virus type 1-infected pregnant women and their neonates. Pediatric AIDS Clinical Trials Group Protocol 250 Team. | |
| | |
MedLine Citation:
|
PMID: 9697716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The safety, toxicity, and pharmacokinetics of intrapartum and early newborn nevirapine were evaluated in 17 human immunodeficiency virus type 1-infected women in labor and their newborns. No adverse effects of nevirapine were noted in any study mothers or infants. Following maternal dosing with 200 mg during labor, concentrations exceeding 100 ng/mL (10 times the in vitro IC50) were achieved in the newborns. Nevirapine elimination was prolonged in both mothers and infants, with median half-lives ranging from 36.8 to 65.7 h. Administration of 200 mg orally to the mothers in labor and of a single 2-mg/kg oral dose to the infants at 48-72 h after birth maintained serum concentrations in the infants > 100 ng/mL through 7 days of life. |
| | |
Authors:
|
M Mirochnick; T Fenton; P Gagnier; J Pav; M Gwynne; S Siminski; R S Sperling; K Beckerman; E Jimenez; R Yogev; S A Spector; J L Sullivan |
Related Documents
:
|
7352486 - Effects of induction of labor on the neurophysiologic functioning of newborn infants. 4076926 - Duration of the third stage of labor in a female yellow baboon from mikumi national par... 11235436 - Regulation of uterine contraction: mechanisms in preterm labor. 17501696 - The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of ... 1804946 - Rapid biometric assessment of gestational age in very low birth weight infants. 3948586 - Tactual habituation and discrimination of form in infancy: a comparison with vision. |
Publication Detail:
|
Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 178 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1998 Aug |
Date Detail:
|
Created Date: 1998-09-04 Completed Date: 1998-09-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 368-74 Citation Subset: AIM; IM; X |
Affiliation:
|
Department of Pediatrics, Boston Medical Center, Massachusetts 02118, USA. markm@bu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anti-HIV Agents / adverse effects, pharmacokinetics*, therapeutic use Cohort Studies Female Follow-Up Studies HIV Infections / drug therapy* HIV-1* Humans Infant Infant, Newborn Nevirapine / adverse effects, pharmacokinetics*, therapeutic use Pregnancy Pregnancy Complications, Infectious / drug therapy* Reverse Transcriptase Inhibitors / adverse effects, pharmacokinetics*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Anti-HIV Agents; 0/Reverse Transcriptase Inhibitors; 129618-40-2/Nevirapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors influencing the emergence of resistance to indinavir: role of virologic, immunologic, and ph...
Next Document: Early prognostic indicators in primary perinatal human immunodeficiency virus type 1 infection: impo...