Document Detail


Pharmacokinetics of nafcillin in patients with renal failure.
MedLine Citation:
PMID:  883823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nafcillin, a pencillinase-resistant penicillin, is frequently used for treatment of staphylococcal infections in hemodialysis patients. Despite its widespread use, there is a paucity of available data regarding the pharmacokinetics of nafcillin in hemodialysis patients. Therefore, sodium nafcillin, 25 mg/kg, was given intravenously over a 5- to 15-min period to 12 hemodialysis patients. Eleven patients were studied during dialysis, and eight of these were studied again during the interdialysis period. The initial serum half-life for nafcillin was 0.208 h during dialyses and 0.278 h between dialyses. The terminal half-life was 1.48 h during dialyses and 1.89 h between dialyses. There was no statistically significant difference between these values. These data indicate that renal failure does not appreciably affect the serum half-life of nafcillin, and hemodialysis does not accelerate the rate of clearance of nafcillin from the blood. Therefore, no modification of the usual nafcillin dosage is necessary when using this drug in hemodialysis patients.
Authors:
C R Diaz; J G Kane; R H Parker; F R Pelsor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  12     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Half-Life
Humans
Kidney Failure, Chronic / blood*
Kinetics
Nafcillin / blood*
Renal Dialysis
Time Factors
Chemical
Reg. No./Substance:
147-52-4/Nafcillin
Comments/Corrections

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