| Pharmacokinetics of methylene blue dye for lymphatic mapping in breast cancer-implications for use in pregnancy. | |
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MedLine Citation:
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PMID: 21167367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: although blue dye is routinely used for lymphatic mapping, it is not used for lymphatic mapping in pregnancy-associated breast cancer, because of concern of fetal risk. METHODS: to investigate the safety of blue dye for lymphatic mapping in pregnant women, the pharmacokinetics of methylene blue dye were examined in 10 nonpregnant women, and the results were extrapolated to estimate maximal fetal exposure to the dye. RESULTS: plasma and urine measurements indicated that the dye quickly distributed from the breast injection site to the circulation, with 32% of the total dose excreted in urine within 48 hours. Combined with existing data on organ distribution of methylene blue, the estimated maximal dose to the fetus is 0.25 mg (5% of the administered dose), likely further reduced by other physiologic factors related to pregnancy. CONCLUSIONS: the analysis suggests that methylene blue dye can be used for lymphatic mapping in pregnancy-associated breast cancer with minimal fetal risk. |
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Authors:
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Sandhya Pruthi; Caroline Haakenson; Brian C Brost; Kanesha Bryant; Joel M Reid; Ravinder Singh; Brian Netzel; Judy C Boughey; Amy C Degnim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of surgery Volume: 201 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 70-5 Citation Subset: AIM; IM |
Copyright Information:
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2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Breast Diagnostic Clinic, Mayo Clinic and Mayo Foundation, Rochester, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast / pathology Breast Neoplasms / pathology* Carcinoma, Ductal, Breast / pathology Carcinoma, Intraductal, Noninfiltrating / pathology Coloring Agents / adverse effects, pharmacokinetics* Female Humans Methylene Blue / adverse effects, pharmacokinetics* Middle Aged Pregnancy Pregnancy Complications, Neoplastic / pathology* Prenatal Exposure Delayed Effects / chemically induced Prenatal Injuries / chemically induced* Sentinel Lymph Node Biopsy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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