| Pharmacokinetics of marbofloxacin in blue and gold macaws (Ara ararauna). | |
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MedLine Citation:
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PMID: 16740085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the pharmacokinetics of marbofloxacin after single IV and orally administered doses in blue and gold macaws. ANIMALS: 10 healthy blue and gold macaws. PROCEDURES: In a crossover study, marbofloxacin (2.5 mg/kg) was administered orally (via crop gavage) to 5 birds and IV to 5 birds. Blood samples were obtained at 0, 0.5, 1, 3, 6, 12, 24, 48, 72, and 96 hours after marbofloxacin administration. After a 4-week washout period, the study was repeated, with the first 5 birds receiving the dose IV and the second 5 birds receiving the dose orally. Serum marbofloxacin concentrations were quantitated by use of a validated liquid chromatography-mass spectrometry assay. RESULTS: After oral administration, mean +/- SD area under the curve was 7.94 +/- 2.08 microg.h/mL, maximum plasma concentration was 1.08 +/- 0.316 microg/mL, and bioavailability was 90.0 +/- 31%. After IV administration of marbofloxacin, the apparent volume of distribution was 1.3 +/- 0.32 L/kg, plasma clearance was 0.29 +/- 0.078 L/h/kg, area under the curve was 9.41 +/- 2.84 microg.h/mL, and the harmonic mean terminal half-life was 4.3 hours. CONCLUSIONS AND CLINICAL RELEVANCE: Single IV and orally administered doses of marbofloxacin were well tolerated by blue and gold macaws. The orally administered dose was well absorbed. Administration of marbofloxacin at a dosage of 2.5 mg/kg, PO, every 24 hours may be appropriate to control bacterial infections susceptible to marbofloxacin in this species. |
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Authors:
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James W Carpenter; Robert P Hunter; John H Olsen; Heather Henry; Ramiro Isaza; David E Koch |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 67 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-02 Completed Date: 2007-04-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 947-50 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Area Under Curve Biological Availability Female Fluoroquinolones / administration & dosage*, blood, pharmacokinetics* Half-Life Injections, Intravenous Male Psittaciformes / blood, metabolism* Quinolones / administration & dosage*, blood, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Fluoroquinolones; 0/Quinolones; 115550-35-1/marbofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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