| Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers. | |
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MedLine Citation:
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PMID: 3342287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of lidocaine and bupivacaine and tri-deuteromethyl-labelled lidocaine and bupivacaine were investigated in healthy volunteers. The deuterium-labelled and the unlabelled form of the drug to be investigated were simultaneously infused in 10 min. Plasma concentrations were determined using a combination of capillary gas chromatography and mass fragmentography. Bi-exponential functions were fitted to the plasma concentration-time data. The mean distribution and elimination half-lives were 8.4 +/- 5.9 min and 96 +/- 26 min for lidocaine, 9.2 +/- 7.0 min and 98 +/- 27 min for deuterium-labelled lidocaine, 15.3 +/- 9.9 min and 111 +/- 32 min for bupivacaine, and 15.2 +/- 10.9 min and 109 +/- 31 min for deuterium-labelled bupivacaine, respectively. The mean volumes of the central compartment and mean steady state volumes of distribution were: lidocaine 37 +/- 151 and 97 +/- 201, deuterium-labelled lidocaine 39 +/- 161 and 98 +/- 181, bupivacaine 27 +/- 111 and 66 +/- 231 and deuterium-labelled bupivacaine 28 +/- 121, and 65 +/- 221, respectively. The respective mean plasma clearances were 0.88 +/- 0.181 min-1, 0.87 +/- 0.181 min-1, 0.61 +/- 0.151 min-1, and 0.62 +/- 0.171 min-1. The results of the study indicate that substitution of a deuterated methyl group does not alter the pharmacokinetics of lidocaine and bupivacaine in healthy subjects. |
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Authors:
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A G Burm; A G de Boer; J W van Kleef; N P Vermeulen; L G de Leede; J Spierdijk; D D Breimer |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 9 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 1988 Jan-Feb |
Date Detail:
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Created Date: 1988-04-06 Completed Date: 1988-04-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 85-95 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, University Hospital, Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bupivacaine / blood, pharmacokinetics* Deuterium Half-Life Humans Lidocaine / blood, pharmacokinetics* Male Metabolic Clearance Rate |
| Chemical | |
Reg. No./Substance:
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137-58-6/Lidocaine; 2180-92-9/Bupivacaine; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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