| Pharmacokinetics of ivermectin after maternal or fetal intravenous administration in sheep. | |
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MedLine Citation:
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PMID: 19000259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In pregnant sheep at 120-130 days of gestational age, a study was undertaken in order to characterize the pharmacokinetics and transplacental exchange of Ivermectin after maternal or fetal intravenous administration. Eight pregnant Suffolk Down sheep of 73.2 +/- 3.7 kg body weight (bw) were surgically prepared in order to insert polyvinyl catheters in the fetal femoral artery and vein and amniotic sac. Following 48 h of recovery, the ewes were randomly assigned to two experimental groups. In group 1, (maternal injection) five ewes were treated with an intravenous bolus of 0.2 mg ivermectin/kg bw. In group 2, (fetal injection) three ewes were injected with an intravenous bolus of 1 mg of ivermectin to the fetus through a fetal femoral vein catheter. Maternal and fetal blood and amniotic fluid samples were taken before and after ivermectin administration for a period of 144 h post-treatment. Samples were analyzed by liquid chromatography (HPLC). A computerized non-compartmental pharmacokinetic analysis was performed and the results were compared by means of the Student t-test. The main pharmacokinetic changes observed in the maternal compartment were increases in the volume of distribution and in the half-life of elimination (t((1/2)beta)). A limited maternal-fetal transfer of ivermectin was evidenced by a low fetal Cmax (1.72 +/- 0.6 ng/mL) and AUC (89.1 +/- 11.4 ng.h/mL). While the fetal administration of ivermectin resulted in higher values of clearance (554.1 +/- 177.9 mL/kg) and lower values of t((1/2)beta) (8.0 +/- 1.4 h) and mean residence time (8.0 +/- 2.9 h) indicating that fetal-placental unit is highly efficient in eliminating the drug as well as limiting the transfer of ivermectin from the maternal to fetal compartment. |
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Authors:
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R Pérez; C Palma; M J Núñez; J Cox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary pharmacology and therapeutics Volume: 31 ISSN: 1365-2885 ISO Abbreviation: J. Vet. Pharmacol. Ther. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-12 Completed Date: 2009-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910920 Medline TA: J Vet Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 406-14 Citation Subset: IM |
Affiliation:
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Laboratorio de Farmacología, Departamento de Ciencias Clínicas, Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, Chile. rubperez@udec.cl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiparasitic Agents / administration & dosage, blood, pharmacokinetics* Area Under Curve Chromatography, High Pressure Liquid Female Fetal Blood / chemistry Fetus / metabolism* Half-Life Injections, Intravenous Ivermectin / administration & dosage, blood, pharmacokinetics* Maternal-Fetal Exchange Metabolic Clearance Rate Pregnancy Pregnancy, Animal / metabolism* Sheep |
| Chemical | |
Reg. No./Substance:
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0/Antiparasitic Agents; 70288-86-7/Ivermectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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