Document Detail

Pharmacokinetics of isoflurane: uptake in the brain.
MedLine Citation:
PMID:  12928584     Owner:  NLM     Status:  MEDLINE    
We studied the effect of the inspired isoflurane concentration (C(I)iso) on the pharmacokinetics of isoflurane uptake in the brain by comparing the isoflurane concentration in internal jugular-bulb blood (Jiso) with that in arterial blood (Aiso), and analyzed this by gas chromatography. Sixteen patients (aged 43-76 years) undergoing colorectal surgery were enrolled, and anesthesia was maintained with a constant C(I)iso of either 1% (group 1, n = 8) or 2% (group 2, n = 8) during the 1st hour of isoflurane anesthesia. Under constant volume-controlled ventilation, we measured the C(I)iso and the end-tidal isoflurane concentration (C(E)iso) at the mouthpiece by infrared analysis. Our results demonstrate that it takes 40 min for the brain tissue concentration to equal Aiso for 1% C(I)iso, and 50 min for 2% C(I)iso. The Aiso (and/or Jiso) for 2% C(I)iso was approximately double when compared to that for 1% C(I)iso. Except during the initial wash-in period of the functional residual capacity in the first 3 min, the differences between C(I)iso and C(E)iso revealed that the body uptake of isoflurane for 2% C(I)iso was twice that for 1% C(I)iso. These results demonstrate that the pharmacokinetics of isoflurane uptake in the brain is time-dependent for Jiso to equal Aiso, and the midpoint between Aiso and Jiso (likely representing the isoflurane concentration in brain tissue) was dependent on C(I)iso.
Chih-Cherng Lu; Shung-Tai Ho; Jhi-Joung Wang; Chih-Shung Wong; Oliver Yao-Pu Hu; Sun-Yran Chang; Chung-Yuan Lin
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology     Volume:  69     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-08-20     Completed Date:  2003-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  102-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, No. 161, Section 6 Minchuan E. Road, Taipei, Taiwan.
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MeSH Terms
Anesthetics, Inhalation / blood,  pharmacokinetics*,  pharmacology
Blood Pressure / drug effects
Brain / metabolism*
Heart Rate / drug effects
Isoflurane / blood,  pharmacokinetics*,  pharmacology
Middle Aged
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

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