| Pharmacokinetics of intravenous immunoglobulin (Sandoglobulin) in neonates. | |
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MedLine Citation:
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PMID: 3520504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sandoglobulin administration to neonates was safe at a dose of 500 mg/kg. GBS-specific IgG was significantly elevated for 14 days postinfusion. Pharmacokinetic studies suggest a two-compartment model with a redistribution phase and terminal elimination phase. A half-life of 11.3 days for the initial phase and 30.7 days for the terminal phase was observed. Further, studies will be necessary to determine if IGIV therapy will be effective in preventing or treating GBS infections in neonates. |
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Authors:
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L E Weisman; G W Fischer; V G Hemming; C C Peck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric infectious disease Volume: 5 ISSN: 0277-9730 ISO Abbreviation: Pediatr Infect Dis Publication Date: 1986 May-Jun |
Date Detail:
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Created Date: 1986-07-07 Completed Date: 1986-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8209468 Medline TA: Pediatr Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S185-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
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metabolism* Enzyme-Linked Immunosorbent Assay Humans Immunization, Passive Immunoglobulin G / metabolism Infant, Newborn Infant, Newborn, Diseases / immunology, metabolism*, therapy Metabolic Clearance Rate Sepsis / immunology, metabolism*, therapy Streptococcal Infections / immunology, metabolism*, therapy Streptococcus agalactiae |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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