Document Detail


Pharmacokinetics of insulin and glucose during insulin infusions to diabetes patients. I. Basal regimen
MedLine Citation:
PMID:  6759841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The model of the vascular bed is presented. With this model, pharmacokinetics of insulin and glucose in diabetics is studied while insulin is infused through a dispenser. Calculations have shown the simulation of prostatic activity function by the insulin dispenser leads to hypoinsulinism in the hepatic vascular bed and to hyperinsulinism in the remaining vascular bed. Insulin supply through the dispenser to any part of the vascular bed, in order to provide normal insulin concentration, is followed by changing in insulin concentration in the another areas of the vascular bed as well as fluctuating of the blood sugar level. So far, to normalize the blood sugar level by means of the current therapeutic methods with the insulin infuser is impossible because the sites of its administration does not topographically fit to normal insulin delivery into the vascular bed.
Authors:
A V Dreval'
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Meditsinskaia tekhnika     Volume:  -     ISSN:  0025-8075     ISO Abbreviation:  Med Tekh     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1305457     Medline TA:  Med Tekh     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  21-6     Citation Subset:  IM    
Vernacular Title:
Farmakokinetika insulina i gliukozy pri infuzionnom vvedenii insulina bol'nym diabetom. I. Bazal'nyĭ rezhim.
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MeSH Terms
Descriptor/Qualifier:
Basal Metabolism*
Blood Glucose / metabolism*
Diabetes Mellitus / blood*,  drug therapy
Humans
Insulin / blood*
Insulin Infusion Systems*
Kinetics
Models, Biological
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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