| Pharmacokinetics of imipenem-cilastatin in patients with renal insufficiency undergoing continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 3377464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In six patients with end-stage renal disease, a single bolus of imipenem-cilastatin (500 mg each) was given either intravenously or intraperitoneally in a randomized crossover protocol such that each patient received the drug by both routes at a 2- to 3-week interval. Drug levels in plasma and the peritoneal dialysis fluid were analyzed at frequent intervals, and various pharmacokinetic variables were calculated for a one-compartment open model. Data obtained in the present study suggest that while no significant difference in peak plasma levels or volume of distribution were noted, the following variables were significantly different for imipenem as compared with cilastatin: elimination half-life, total plasma clearance, area under the concentration-time curve, and percent drug excretion in the peritoneal dialysis fluid. The elimination half-life of imipenem (3.28 h) or cilastatin (8.84 h) in our patients was in the same range as observed in patients with minimal renal function undergoing hemodialysis. The dose of imipenem-cilastatin should be reduced appropriately in patients with end-stage renal disease undergoing peritoneal dialysis. |
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Authors:
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P Somani; E H Freimer; M L Gross; J T Higgins |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 32 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-06-27 Completed Date: 1988-06-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 530-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Medical College of Ohio, Toledo 43699. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cilastatin Cyclopropanes / administration & dosage, pharmacokinetics Drug Combinations / administration & dosage, pharmacokinetics Humans Imipenem Injections, Intraperitoneal Injections, Intravenous Kidney Failure, Chronic / metabolism* Peritoneal Dialysis, Continuous Ambulatory* Thienamycins / administration & dosage, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Cyclopropanes; 0/Drug Combinations; 0/Thienamycins; 74431-23-5/Imipenem; 82009-34-5/Cilastatin; 92309-29-0/cilastatin, imipenem drug combination |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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