Document Detail


Pharmacokinetics of imipenem-cilastatin in patients with renal insufficiency undergoing continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  3377464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In six patients with end-stage renal disease, a single bolus of imipenem-cilastatin (500 mg each) was given either intravenously or intraperitoneally in a randomized crossover protocol such that each patient received the drug by both routes at a 2- to 3-week interval. Drug levels in plasma and the peritoneal dialysis fluid were analyzed at frequent intervals, and various pharmacokinetic variables were calculated for a one-compartment open model. Data obtained in the present study suggest that while no significant difference in peak plasma levels or volume of distribution were noted, the following variables were significantly different for imipenem as compared with cilastatin: elimination half-life, total plasma clearance, area under the concentration-time curve, and percent drug excretion in the peritoneal dialysis fluid. The elimination half-life of imipenem (3.28 h) or cilastatin (8.84 h) in our patients was in the same range as observed in patients with minimal renal function undergoing hemodialysis. The dose of imipenem-cilastatin should be reduced appropriately in patients with end-stage renal disease undergoing peritoneal dialysis.
Authors:
P Somani; E H Freimer; M L Gross; J T Higgins
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  32     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  530-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, Medical College of Ohio, Toledo 43699.
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MeSH Terms
Descriptor/Qualifier:
Cilastatin
Cyclopropanes / administration & dosage,  pharmacokinetics
Drug Combinations / administration & dosage,  pharmacokinetics
Humans
Imipenem
Injections, Intraperitoneal
Injections, Intravenous
Kidney Failure, Chronic / metabolism*
Peritoneal Dialysis, Continuous Ambulatory*
Thienamycins / administration & dosage,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Cyclopropanes; 0/Drug Combinations; 0/Thienamycins; 74431-23-5/Imipenem; 82009-34-5/Cilastatin; 92309-29-0/cilastatin, imipenem drug combination
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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