Document Detail


Pharmacokinetics of high and moderate intravenous doses of methotrexate.
MedLine Citation:
PMID:  3363225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetic parameters of methotrexate in nine cancer patients receiving 250-2500 mg/day were investigated. Both elimination rate constants and half-lives were calculated using a two-compartmental open model. The plasma levels-time profiles revealed a biphasic response with a mean initial elimination half-life of 2.3 +/- 0.2 hours and a terminal elimination half-life of 32.2 +/- 7.2 hours.
Authors:
A Awidi; A al-Turk; F Madanat; S Othman; O Shaheen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  59     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-4     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, University of Jordan, Amman.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Half-Life
Humans
Injections, Intravenous
Methotrexate / administration & dosage,  pharmacokinetics*
Middle Aged
Models, Biological
Neoplasms / metabolism
Chemical
Reg. No./Substance:
59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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