Document Detail

Pharmacokinetics of high and moderate intravenous doses of methotrexate.
MedLine Citation:
PMID:  3363225     Owner:  NLM     Status:  MEDLINE    
The pharmacokinetic parameters of methotrexate in nine cancer patients receiving 250-2500 mg/day were investigated. Both elimination rate constants and half-lives were calculated using a two-compartmental open model. The plasma levels-time profiles revealed a biphasic response with a mean initial elimination half-life of 2.3 +/- 0.2 hours and a terminal elimination half-life of 32.2 +/- 7.2 hours.
A Awidi; A al-Turk; F Madanat; S Othman; O Shaheen
Related Documents :
8737765 - Influence of repeated oral doses of ethinyloestradiol on the metabolic disposition of [...
2373665 - Pharmacokinetics and tissue penetration of cefprozil.
10440795 - Physiologically based pharmacokinetics of kni-272, a tripeptide hiv-1 protease inhibitor.
17665185 - Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator geno...
2226625 - Stereospecific inhibition of non-opioid defeat analgesia in male mice by mdl 72832, a s...
6201525 - Comparative carcinogenic and mutagenic activity of coal tar and petroleum asphalt paint...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  59     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-4     Citation Subset:  IM    
Faculty of Medicine, University of Jordan, Amman.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Injections, Intravenous
Methotrexate / administration & dosage,  pharmacokinetics*
Middle Aged
Models, Biological
Neoplasms / metabolism
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clotrimazole.
Next Document:  Effect of cimetidine on in vivo formation of adducts between metabolites of benzo(a)pyrene and DNA.