| Pharmacokinetics and hemodynamic effects of tiapamil: exercise performance, thallium stress scintigraphy, and radionuclide ventriculography. | |
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MedLine Citation:
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PMID: 6725618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetic behavior and hemodynamic effects of tiapamil, a calcium antagonist, were studied in 16 cardiac patients during an eight-day treatment course, giving oral doses of 600 mg daily. The hemodynamic effects were investigated using exercise performance tests, thallium stress scintigraphy, and radionuclide ventriculography. The areas under the plasma concentration-time curve after the final dose were greater than after the first dose for both tiapamil (+53 per cent) and its metabolite (+24 per cent). One possible explanation is that tiapamil undergoes saturable intestinal wall metabolism. Alternatively, like verapamil, it may undergo a saturable hepatic elimination process. The hemodynamic test series showed that, despite increasing the exercise tolerance, tiapamil significantly reduced the rate-pressure product, an index of myocardial oxygen requirement. Regional myocardial perfusion clearly improved. Ventriculography showed a significant increase in ejection fraction (+18 per cent), cardiac index (+12 per cent), and stroke volume index (+19 per cent). At the same time, the measured mean arterial pressure decreased significantly by about 10 per cent and the calculated peripheral vascular resistance, by about 19 per cent. |
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Authors:
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M Eckert; H Pozenel; B Pillat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 24 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-07-25 Completed Date: 1984-07-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 165-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Arrhythmia Agents
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blood*,
pharmacology Blood Pressure / drug effects Calcium Channel Blockers Electrocardiography Exercise Test Female Heart / radionuclide imaging* Heart Rate / drug effects Hemodynamics / drug effects* Humans Kinetics Male Middle Aged Propylamines / blood*, pharmacology Thallium / diagnostic use Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Calcium Channel Blockers; 0/Propylamines; 57010-31-8/dimeditiapramine; 7440-28-0/Thallium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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