Document Detail


Pharmacokinetics and feeding responses to muramyl dipeptide in rats.
MedLine Citation:
PMID:  12834788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-acetyl-muramyl-L-alanine-D-isoglutamine or muramyl dipeptide (MDP) is the minimally active subunit of bacterial peptidoglycan. During a systemic infection, the involvement of MDP has been demonstrated in food intake depression by the macrophage hydrolysis of Gram-positive bacteria. Under normal conditions, mammals are constantly exposed to the release of endogenous MDP from degraded gut flora and that of exogenous MDP from the diet. However, MDP digestion and absorption in the gastrointestinal tract are not fully understood, and their physiological significance needs to be clarified. After gavage (1.5 mg/kg), very low levels of MDP were found in the systemic circulation of rats and feeding patterns were not altered. In contrast, after the intraperitoneal injection of a similar dose, a depression in food intake was observed. The rats reduced their meal frequency and constant feeding rate, showing signs of satiety. The behavioral satiety sequence (BSS) was modified by behavioral changes, similar to those which appear during sickness, such as an increase in resting and a reduction in grooming. Our data suggest that the hypophagic effect of MDP may result from satiety and sickness behavior.
Authors:
Sophie Fosset; Gilles Fromentin; Olivier Rampin; Vincent Lang; Florence Mathieu; Daniel Tomé
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  79     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-01     Completed Date:  2003-10-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-82     Citation Subset:  IM    
Affiliation:
Unité INRA/INAPG de Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique de Paris-Grignon, 16 rue Claude Bernard, F-75231, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Acetylmuramyl-Alanyl-Isoglutamine / administration & dosage,  blood,  pharmacokinetics*,  pharmacology*
Animals
Behavior, Animal / drug effects
Eating / drug effects*
Injections, Intraperitoneal
Injections, Intravenous
Intubation, Gastrointestinal
Male
Rats
Rats, Sprague-Dawley
Rest
Satiety Response / drug effects
Chemical
Reg. No./Substance:
53678-77-6/Acetylmuramyl-Alanyl-Isoglutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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