Document Detail


Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs.
MedLine Citation:
PMID:  19000270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to describe and compare the pharmacokinetic properties of different formulations of erythromycin in dogs. Erythromycin was administered as lactobionate (10 mg/kg, IV), estolate tablets (25 mg/kg p.o.) and ethylsuccinate tablets or suspension (20 mg/kg p.o.). After intravenous (i.v.) administration, the principal pharmacokinetic parameters were (mean +/- SD): AUC((0-infinity)) 4.20 +/- 1.66 microg x h/mL; C(max) 6.64 +/- 1.38 microg/mL; V(z) 4.80 +/- 0.91 L/kg; Cl(t) 2.64 +/- 0.84 L/h.kg; t((1/2)lambda) 1.35 +/- 0.40 h and MRT 1.50 +/- 0.47 h. After the administration of estolate tablets and ethylsuccinate suspension, the principal pharmacokinetic parameters were (mean +/- SD): C(max), 0.30 +/- 0.17 and 0.17 +/- 0.09 microg/mL; t(max), 1.75 +/- 0.76 and 0.69 +/- 0.30 h; t((1/2)lambda), 2.92 +/- 0.79 and 1.53 +/- 1.28 h and MRT, 5.10 +/- 1.12 and 2.56 +/- 1.77 h, respectively. The administration of erythromycin ethylsuccinate tablets did not produce measurable serum concentrations. Only the i.v. administration rendered serum concentrations above MIC(90) = 0.5 microg/mL for 2 h. However, these results should be cautiously interpreted as tissue erythromycin concentrations have not been measured in this study and, it is recognized that they can reach much higher concentrations than in blood, correlating better with clinical efficacy.
Authors:
G A Albarellos; V E Kreil; L A Ambros; S Waxman; L Montoya; L Tarragona; P C Quaine; R E Hallu; M Rebuelto
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  31     ISSN:  1365-2885     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  496-500     Citation Subset:  IM    
Affiliation:
Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires, Argentina. albarell@fvet.uba.ar
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anti-Bacterial Agents / administration & dosage*,  blood,  pharmacokinetics*
Area Under Curve
Cross-Over Studies
Dogs
Dosage Forms
Erythromycin Estolate / administration & dosage*,  blood,  pharmacokinetics*
Erythromycin Ethylsuccinate / administration & dosage,  blood,  pharmacokinetics*
Female
Half-Life
Injections, Intravenous
Linear Models
Male
Metabolic Clearance Rate
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Dosage Forms; 1264-62-6/Erythromycin Ethylsuccinate; 3521-62-8/Erythromycin Estolate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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