| Pharmacokinetics and efficacy of carvedilol in hypertensive patients with chronic renal failure and hemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 1378134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The efficacy, safety, and pharmacokinetics of carvedilol were investigated in an open trial performed on 13 hypertensive patients with chronic renal failure and six additional patients requiring hemodialysis. In hypertensive renal failure patients, treatment with carvedilol (5 mg/day) for 1 week produced a significant decrease in blood pressure (from 172/101 to 146/84 mm Hg) but did not change the heart rate. The pharmacokinetics of carvedilol did not change with repeated administration, and there was no accumulation of this drug. In hemodialysis patients with hypertension, the pharmacokinetics of carvedilol after a single dose of 10 mg did not vary between dialysis and nondialysis days, and blood pressure decreased significantly on both days. In addition, there was no accumulation of carvedilol during a 4-week trial of therapy, and blood pressure was decreased significantly from 170/93 to 145/83 mm Hg. There were no side effects and no abnormal laboratory findings noted during the trial. These results indicate that carvedilol is an effective and safe agent for hypertensive patients with chronic renal failure and for hemodialysis patients with hypertension and that dosage adjustments are probably not required in these clinical situations. |
| | |
Authors:
|
H Masumura; S Miki; Y Kaifu; W Kitajima; Y Abe |
Related Documents
:
|
9928754 - Verapamil sr/trandolapril combination therapy for the elderly hypertensive patient. ger... 12975714 - A retrospective review of the effect of cox-2 inhibitors on blood pressure change. 7607734 - Trends in the prevalence, awareness, treatment, and control of hypertension in the adul... 16296704 - Open evaluation of amlodipine in the monotherapeutic treatment of systolic hypertension... 8356864 - Effects of propofol on mean arterial pressure and systemic vascular resistance during c... 9769234 - Depressed myofilament co-operativity associated with post-cardioplegic myocardial depre... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 19 Suppl 1 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1992 |
Date Detail:
|
Created Date: 1992-08-07 Completed Date: 1992-08-07 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: S102-7 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Kagawa Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
pharmacokinetics*,
therapeutic use Blood Pressure / drug effects Blood Urea Nitrogen Carbazoles / pharmacokinetics*, therapeutic use Creatinine / blood Female Heart Rate / drug effects Humans Hypertension / complications, drug therapy*, metabolism Kidney Failure, Chronic / complications*, metabolism Male Middle Aged Propanolamines / pharmacokinetics*, therapeutic use Renal Dialysis* Vasodilator Agents / pharmacokinetics*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0/Vasodilator Agents; 60-27-5/Creatinine; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Beta-blocking agents with vasodilating action.
Next Document: Effects of carvedilol during exercise.