Document Detail


Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane.
MedLine Citation:
PMID:  7639356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In conflict with the prediction of the Meyer-Overton hypothesis, perfluoropropane (C3F8) and perfluoropentane (C5F12) have no anesthetic effect in rats. To test whether this resulted from a failure of the inspired drugs to reach the brain, we determined the increase in partial pressures of C3F8 and C5F12 in the blood and brains of rats exposed to 0.65 ata of each drug. C3F8 and C5F12 blood/gas partition coefficients equaled 0.00125 +/- 0.00037 (mean +/- SD, n = 9) and 0.00277 +/- 0.00082 (n = 4), and brain/gas partition coefficients equaled 0.0119 +/- 0.0002 (n = 4) and 0.0229 +/- 0.0055 (n = 7), respectively. As a fraction of the inspired value (Pa/PI), the partial pressures of C3F8 and C5F12 in blood (Pa) were 0.99 +/- 0.12 and 0.69 +/- 0.19, respectively, 30 min after administration. The increases in cerebral (Pb) partial pressures of both drugs paralleled the arterial increases (Pb/PI = 0.85 +/- 0.02, and 1.05 +/- 0.03, respectively at 30 min), with C3F8 reaching a plateau at 2 h of 96% +/- 4% of the partial pressure of inspired gas. We conclude that failure of C3F8 and C5F12 to reach the brain does not account for the absence of an anesthetic effect of these compounds.
Authors:
B S Chortkoff; M J Laster; D D Koblin; S Taheri; E I Eger; M J Halsey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  79     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-09-12     Completed Date:  1995-09-12     Revised Date:  2008-05-30    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, University of California, San Francisco 94143-0648, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation
Animals
Blood-Brain Barrier / drug effects
Brain / metabolism*
Fluorocarbons / pharmacokinetics*,  pharmacology
Male
Rats
Rats, Sprague-Dawley
Specific Pathogen-Free Organisms
Chemical
Reg. No./Substance:
0/Fluorocarbons; 678-26-2/perfluoropentane; 76-19-7/perflutren

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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