Document Detail


Pharmacokinetics and distribution over the blood brain barrier of two acyclic guanosine analogs in rats, studied by microdialysis.
MedLine Citation:
PMID:  1605599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The free extracellular concentrations of acyclovir and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) in the blood and in brain tissue of rats were measured in microdialysis samples by high-pressure liquid chromatography with UV detection. The half-life of acyclovir in blood was 2 h, while that of H2G was 28 min. The concentration attained in the brain compared with the concentration in blood was slightly lower for H2G than for acyclovir. The results show that the pharmacokinetic profiles of acyclic nucleosides may vary as a consequence of the structure of the acyclic chain corresponding to the sugar moiety.
Authors:
L Ståhle; B Oberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  36     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-42     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Acyclovir / analogs & derivatives*,  blood,  pharmacokinetics*
Animals
Antiviral Agents / blood,  pharmacokinetics*
Blood Proteins / metabolism
Blood-Brain Barrier*
Dialysis
Male
Octanols
Protein Binding
Rats
Rats, Inbred Strains
Tissue Distribution
Water
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Blood Proteins; 0/Octanols; 117191-32-9/9-(4-hydroxy-2-(hydroxymethyl)butyl)-guanine triphosphate; 59277-89-3/Acyclovir; 7732-18-5/Water
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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