Document Detail

Pharmacokinetics of cyclosporin: influence of rate of constant intravenous infusion in renal transplant patients.
MedLine Citation:
PMID:  3318898     Owner:  NLM     Status:  MEDLINE    
1 The pharmacokinetics of cyclosporin were studied in 12 renal transplant patients. Five patients received a constant rate (7 mg kg-1 day-1) intravenous infusion over 72 h and the remainder received rates of 7, 4 and 10 mg kg-1 day-1, consecutively each for at least 24 h. 2 Plasma, separated at 37 degrees C, was analysed by h.p.l.c. 3 The data were best described by a biexponential model. 4 Following the 72 h infusion, a plateau was reached by 24 h and clearance was 0.60 l h-1 kg-1. 5 Clearance associated with the 10 mg kg-1 day-1 infusion rate (0.43 l h-1 kg-1) was estimated to be lower than that following the 4 and 7 mg kg-1 day-1 rates (0.52 and 0.54 l h-1 kg-1 respectively) but the difference is unlikely to be of clinical significance.
S K Gupta; B Legg; L R Solomon; R W Johnson; M Rowland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  24     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-10     Completed Date:  1988-02-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  519-26     Citation Subset:  IM    
Department of Pharmacy, University of Manchester.
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MeSH Terms
Chromatography, High Pressure Liquid
Cyclosporins / administration & dosage,  blood,  pharmacokinetics*
Infusions, Intravenous
Kidney Transplantation*
Models, Biological
Reg. No./Substance:

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