Document Detail


Pharmacokinetics of ciprofloxacin in the elderly.
MedLine Citation:
PMID:  3659579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of ciprofloxacin, administered orally as a 250-mg tablet were compared in 10 young (age 20-30 years) and 10 elderly (age 60-73 years) healthy volunteers. The time to peak serum concentrations was about 80 min in both age groups, although the maximum concentration attained was significantly greater in the old (1.7 mg/l) than the young (1.2 mg/l). Area under the plasma concentration-time curve, corrected for body weight, was on average 48% greater in the elderly, but the mean terminal elimination half-life was not significantly different, averaging 4.3 h in the old and 3.7 h in the young. Overall 24-hour urinary recovery in both age groups was comparable. The differences may be explained by a reduced volume of distribution of ciprofloxacin in old age and do not suggest a general need for significant dose alteration in the elderly.
Authors:
A Bayer; A Gajewska; M Stephens; J M Stark; J Pathy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  51     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-12     Completed Date:  1987-11-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, University of Wales College of Medicine, Cardiff, UK.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Aging / metabolism*
Biological Availability
Ciprofloxacin / blood,  pharmacokinetics*,  urine
Female
Half-Life
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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