| Pharmacokinetics of ceftazidime in premature, newborn and young infants. | |
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MedLine Citation:
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PMID: 6374925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of ceftazidime, a new injectable broad-spectrum cephalosporin with high anti-pseudomonal activity, were studied in 50 preterm, full-term and young infants after an intravenous bolus dose of 30 mg/kg. The serum concentrations of ceftazidime were higher in the younger babies, both premature and full-term. In infants over 2 months of age blood levels were similar to those of adult volunteer subjects. No untoward effects were encountered. Considering the in vitro activity of ceftazidime against a wide spectrum of pathogenic bacteria, the present dose schedules, 25-50 mg/kg/d for babies less than 2 months of age and 50-100 mg/kg/d for those 2-12 months of age, appear to be appropriate. Until more experience is gained with ceftazidime in neonates, monitoring of trough levels to ensure adequate blood concentrations would be ideal. |
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Authors:
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J G Prinsloo; S D Delport; J Moncrieff; A M Paton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 65 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-07-05 Completed Date: 1984-07-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 809-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Ceftazidime Cephalosporins / blood, metabolism* Half-Life Humans Infant Infant, Newborn Infant, Premature Kinetics |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 78439-06-2/Ceftazidime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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