Document Detail

Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses.
MedLine Citation:
PMID:  19165935     Owner:  NLM     Status:  MEDLINE    
REASON FOR PERFORMING STUDY: Current therapy protocols to treat persistent post mating endometritis and retained fetal membranes in mares typically include the administration of ecbolic drugs. Evaluation of the pharmacokinetics and tolerability of carbetocin, a long-acting oxytocin analogue, after i.v. administration is required. OBJECTIVES: To determine the pharmacokinetic parameters (principally half-life) of carbetocin in horses. METHODS: Five mature mares and one gelding received 0.175 mg carbetocin i.v. All animals were monitored periodically throughout the study for elevation in rectal temperature, heart rate, respiratory rate and signs of pain or discomfort. Plasma samples were collected for determination of carbetocin concentrations by radioimmunoassay. RESULTS: Administration of carbetocin was well tolerated by all horses and its half-life was 17.2 min. CONCLUSIONS: The half-life of carbetocin is greater than that previously reported for oxytocin (6.8 min). POTENTIAL RELEVANCE: Carbetocin is an attractive alternative to oxytocin therapy in broodmare management.
A R Schramme; C R F Pinto; J Davis; C S Whisnant; M D Whitacre
Related Documents :
9259815 - The effect of an acute angulation of the hind hooves on diagonal synchrony of trotting ...
8174435 - Strenuous exercise decreases motility and cross-sectional area of human gastric antrum....
8482185 - Integration of canine proximal gastric, antral, pyloric, and proximal duodenal motility...
15892235 - Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of n...
15708875 - Dynamics of skeletal muscle oxygenation during sequential bouts of moderate exercise.
10895805 - Electrovesicogram in stress urinary incontinence: a preliminary study.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  40     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  658-61     Citation Subset:  IM    
North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Area Under Curve
Heart Rate / drug effects
Horse Diseases / blood,  drug therapy
Horses / blood*
Injections, Intravenous / veterinary
Oxytocin / adverse effects,  analogs & derivatives*,  pharmacokinetics,  therapeutic use
Pain / chemically induced,  epidemiology,  veterinary
Radioimmunoassay / veterinary
Respiration / drug effects
Reg. No./Substance:
37025-55-1/carbetocin; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Days lost from training by two- and three-year-old Thoroughbred horses: a survey of seven UK trainin...
Next Document:  Histological and ultrastructural evidence that recurrent laryngeal neuropathy is a bilateral mononeu...