| Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses. | |
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MedLine Citation:
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PMID: 19165935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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REASON FOR PERFORMING STUDY: Current therapy protocols to treat persistent post mating endometritis and retained fetal membranes in mares typically include the administration of ecbolic drugs. Evaluation of the pharmacokinetics and tolerability of carbetocin, a long-acting oxytocin analogue, after i.v. administration is required. OBJECTIVES: To determine the pharmacokinetic parameters (principally half-life) of carbetocin in horses. METHODS: Five mature mares and one gelding received 0.175 mg carbetocin i.v. All animals were monitored periodically throughout the study for elevation in rectal temperature, heart rate, respiratory rate and signs of pain or discomfort. Plasma samples were collected for determination of carbetocin concentrations by radioimmunoassay. RESULTS: Administration of carbetocin was well tolerated by all horses and its half-life was 17.2 min. CONCLUSIONS: The half-life of carbetocin is greater than that previously reported for oxytocin (6.8 min). POTENTIAL RELEVANCE: Carbetocin is an attractive alternative to oxytocin therapy in broodmare management. |
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Authors:
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A R Schramme; C R F Pinto; J Davis; C S Whisnant; M D Whitacre |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Equine veterinary journal Volume: 40 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: England |
Other Details:
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Languages: eng Pagination: 658-61 Citation Subset: IM |
Affiliation:
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North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Female Half-Life Heart Rate / drug effects Horse Diseases / blood, drug therapy Horses / blood* Injections, Intravenous / veterinary Oxytocin / adverse effects, analogs & derivatives*, pharmacokinetics, therapeutic use Pain / chemically induced, epidemiology, veterinary Radioimmunoassay / veterinary Respiration / drug effects |
| Chemical | |
Reg. No./Substance:
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37025-55-1/carbetocin; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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