| Pharmacokinetics of calcium absorption from two commercial calcium supplements. | |
| | |
MedLine Citation:
|
PMID: 10579145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was conducted to compare pharmacokinetic indices of calcium absorption after a single oral (500 mg calcium) load of Citracal (calcium citrate) and Os-Cal (calcium carbonate). In 18 postmenopausal normal women, venous blood samples were obtained for the measurement of calcium before and hourly for 6 hours after an oral ingestion of Citracal, Os-Cal, or placebo with a breakfast meal. The change in area under the curve (delta AUC) in serum calcium from preload was 2.5-fold greater for Citracal than Os-Cal, and the peak-basal variation in serum calcium was 76% higher for Citracal than Os-Cal. The increment in serum calcium from preload after Citracal administration was significantly higher than that obtained after placebo load during most time periods and significantly higher than that of Os-Cal at 1, 4, and 5 hours after load. In contrast, delta AUC and peak basal variation of Os-Cal did not differ significantly from placebo and increment in serum calcium was significantly increased from placebo only at 6 hours. In conclusion, Citracal is much more bioavailable than Os-Cal. |
| | |
Authors:
|
H J Heller; A Stewart; S Haynes; C Y Pak |
Related Documents
:
|
8243525 - Cica-clamp technique: a method for quantifying parathyroid hormone secretion: a sequent... 6705285 - Renal side effect of nifedipine. 2446585 - Calcium and phosphate metabolism in uranyl nitrate-induced acute renal failure. 58255 - Metabolic fate of administered 1,25-dihydroxycholecalciferol in controls and in patient... 2140925 - Alteration of retinol-binding-protein concentrations by the synthetic retinoid fenretin... 18789615 - Prediction of the estrous cycle and optimal insemination time by monitoring vaginal ele... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of clinical pharmacology Volume: 39 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-12-16 Completed Date: 1999-12-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1151-4 Citation Subset: IM; S |
Affiliation:
|
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75235-8885, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Aged Area Under Curve Calcium / blood, pharmacokinetics* Calcium Carbonate / administration & dosage, blood, pharmacokinetics* Calcium Citrate / administration & dosage, blood, pharmacokinetics* Cross-Over Studies Female Humans Middle Aged Postmenopause / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
M01-RR00633/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
471-34-1/Calcium Carbonate; 5785-44-4/Calcium Citrate; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacokinetics of clinafloxacin enantiomers in humans.
Next Document: The effect of a high-fat meal on the oral bioavailability of the immunosuppressant sirolimus (rapamy...