| Pharmacokinetics of cadmium following intravenous and oral administration to non-lactating ewes. | |
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MedLine Citation:
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PMID: 7795664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a preliminary study, ewes received daily oral cadmium chloride administrations and cadmium concentration was measured in blood and tissues. A pharmacokinetic analysis of cadmium disposition was then carried out in ewes administered cadmium chloride iv and, 21 months later, orally in the same ewes. Pharmacokinetic parameters were analysed using a 3-compartment open model. The systemic availability was 0.15-0.5%, the half-life of elimination was 100-150 d, the blood clearance was 0.12-0.16 l.kg-1.d-1 and the steady-state volume of distribution was 17-35 l/kg. Following iv administration cadmium was found in tissues about 2 years later. |
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Authors:
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P Houpert; S Mehennaoui; B Joseph-Enriquez; B Federspiel; G Milhaud |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary research Volume: 26 ISSN: 0928-4249 ISO Abbreviation: Vet. Res. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-07-31 Completed Date: 1995-07-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9309551 Medline TA: Vet Res Country: FRANCE |
Other Details:
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Languages: eng Pagination: 145-54 Citation Subset: IM |
Affiliation:
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Ecole nationale vétérinaire d'Alfort, service de pharmacie et toxicologie, Maisons-Alfort, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Cadmium / administration & dosage, pharmacokinetics* Diet Female Injections, Intravenous Sheep / blood, metabolism* Spectrophotometry, Atomic / veterinary Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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