Document Detail


Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration.
MedLine Citation:
PMID:  14710109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine the pharmacokinetics of betamethasone in maternal and fetal circulations after maternal or fetal intramuscular administration. STUDY DESIGN: Ewes that bore single fetuses underwent surgery at approximately 96 days of pregnancy for the implantation of fetal and maternal vascular catheters. At approximately 103 days, five ewes were injected intramuscularly with betamethasone (0.5 mg/kg body weight) or five fetuses received ultrasound-guided intramuscular injections of betamethasone (0.5 mg/kg estimated fetal weight). Maternal and fetal blood samples were collected serially for the measurement of plasma betamethasone concentrations. RESULTS: Fetal injection caused higher peak fetal betamethasone concentrations (341.2+/-23.7 nmol/L) than maternal injection (37.6+/-3.7 nmol/L; P<.001) and greater cumulative betamethasone exposure. The half-life of betamethasone in the fetal circulation was shorter after fetal injection (1.1+/-0.3 hours) than after maternal injection (8.5+/-2.0 hours; P=.006). CONCLUSION: The duration of fetal and maternal exposure to betamethasone can be minimized by direct fetal intramuscular administration that, in sheep, affords lung maturation without adverse effects on fetal growth.
Authors:
Timothy J M Moss; Dorota A Doherty; Ilias Nitsos; Richard Harding; John P Newnham
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  189     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-07     Completed Date:  2004-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1751-7     Citation Subset:  AIM; IM    
Affiliation:
Lotteries Commission Perinatal Research Laboratories, School of Women's and Infants' Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia. tmoss@cyllene@uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Betamethasone / administration & dosage,  pharmacokinetics*
Female
Fetus / drug effects*
Injections, Intramuscular
Maternal-Fetal Exchange / drug effects*
Models, Animal
Pregnancy
Pregnancy, Animal / drug effects*
Probability
Sensitivity and Specificity
Sheep
Statistics, Nonparametric
Tissue Distribution
Chemical
Reg. No./Substance:
378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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