| Pharmacokinetics of azlocillin in normal renal function: single and repetitive dosing studies. | |
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MedLine Citation:
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PMID: 6619035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic and urinary pharmacokinetic studies of the disposition of azlocillin were performed in seven male and six female healthy volunteers. Four separate studies identified the kinetics of the drug following a single 2, 3 or 4 g administration and during the repetitive administrations of 3 g of the drug over a five-day period. Peak plasma concentrations were 174 +/- 19 mg/l, 214 +/- 17 mg/l and 286 +/- 11 mg/l in the 2, 3 and 4 g single dose studies respectively. Trough values at 4 h post-dosing were 6 +/- 1 mg/l, 10 +/- 1 mg/l and 26 +/- 3 mg/l respectively. The plasma half-life of azlocillin was approximately 60 min. A dose-dependent phenomenon was observed. This was characterized by a slight but significant progressive increase in the plasma half-life of the drug as increasing amounts of drug were given and as the same amount was given repeatedly. No significant systemic accumulation of azlocillin was noted during the repetitive dosing study. The urinary excretion of the compound was prompt with most of the bioactive drug being eliminated in the first 4-6 h following dosing. The apparent volume of distribution of azlocillin was slightly greater than the extracellular fluid compartment. For the therapy of systemic infections in adults with normal renal function a 4 h or 6 h dosing cycle would be appropriate. |
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Authors:
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F A Delgado; R L Stout; A Whelton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 11 Suppl B ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 79-88 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Azlocillin Female Half-Life Humans Kidney / physiology Kinetics Male Penicillins / administration & dosage, metabolism*, urine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Penicillins; 37091-66-0/Azlocillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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