Document Detail

Pharmacokinetics of amphotericin B in serum and tissues in mice treated with amphotericin B-Intralipid.
MedLine Citation:
PMID:  12627800     Owner:  NLM     Status:  MEDLINE    
In our previous research we studied the efficacy of amphotericin B (AMB)-Intralipid (AMB-IL) admixtures in the treatment of experimental systemic candidosis in naïve and compromised mice. In this study we evaluated the levels of AMB in blood and several organs (kidneys, liver, spleen, lungs and heart) at different times after injection (from 5 min to 14 days). Comparisons were made with levels occurring in animals treated with Fungizone or AmBisome. A sensitive high-pressure liquid chromatography (HPLC) method was adapted for assaying AMB in blood and tissues. We used reversed-phased column and a simple mobile phase consisting of acetonitrile and EDTA. We found that blood levels of AMB in mice injected with AMB-IL were higher than those obtained in animals treated with Fungizone, but similar to those obtained in mice administered AmBisome. Compared with conventional Fungizone therapy, administration of lipid formulations of AMB (both AMB-IL and AmBisome) resulted in higher concentrations of AMB in the liver and spleen, but lower concentrations in the kidneys and lungs.
Y Shadkchan; Z Zaslavsky; E Segal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical mycology     Volume:  41     ISSN:  1369-3786     ISO Abbreviation:  Med. Mycol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-11     Completed Date:  2003-05-08     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
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MeSH Terms
Amphotericin B / administration & dosage,  pharmacokinetics*
Biological Availability
Fat Emulsions, Intravenous / administration & dosage*
Mice, Inbred ICR
Tissue Distribution
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 7XU7A7DROE/Amphotericin B

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