Document Detail

Pharmacokinetics of amikacin in children with normal and impaired renal function.
MedLine Citation:
PMID:  7300106     Owner:  NLM     Status:  MEDLINE    
The pharmacokinetics of the antibiotic amikacin sulfate were studied in eight children with normal renal function and in ten children with varying degrees of renal impairment. All patients received a single i.v. dose of 7.5 mg/kg of the antibiotic. Amikacin follows a two-compartment open-kinetic model. The serum half-life, which in children with normal renal function has an average value of 1 hour, reached values of 14 hours in children with severe renal impairment. A lineal relationship is established between the beta constant and the creatinine clearance (Clcr) according to the equation beta = 0.001 + 0.005.Clcr, with r = 0,818. From thie equation, the dosage interval is modified to maintain the serum concentrations of the antibiotic within the therapeutic interval.
J M Lanao; A A Dominguez-Gil; A Dominguez-Gil; S Málaga; M Crespo; F Santos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  20     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  IM    
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MeSH Terms
Amikacin / blood,  metabolism*
Child, Preschool
Kanamycin / analogs & derivatives*
Kidney Diseases / metabolism*
Reg. No./Substance:
37517-28-5/Amikacin; 59-01-8/Kanamycin

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