Document Detail

Pharmacokinetics of alkylresorcinol metabolites in human urine.
MedLine Citation:
PMID:  21481288     Owner:  NLM     Status:  Publisher    
Wholegrain cereals are reported to promote beneficial health effects. Wholegrain wheat and rye are almost exclusive sources of alkylresorcinols, and intact alkylresorcinols together with their plasma and urinary metabolites, 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), have been proposed as biomarkers of the intake of these foods in humans. The pharmacokinetics of alkylresorcinols and their metabolites in plasma have been determined but not that of the urinary metabolites. We aimed to characterise the urinary pharmacokinetics of alkylresorcinol metabolites in humans to evaluate their potential as biomarkers of wholegrain wheat and rye. A group of fifteen volunteers followed a low-alkylresorcinol diet for 2 d before ingesting a single dose of rye bread, containing 100 mg alkylresorcinols. Urine was collected between baseline (0 h) and 25 h after administration. Thereafter alkylresorcinol metabolites were quantified by HPLC with coulometric electrode array detection. Maximum excretion rates were observed at 5-6 h for both metabolites, DHPPA being predominant over DHBA and also possessing a greater area under the curve0-25 h. Total urinary recovery between 0 and 25 h yielded 43 % of ingested alkylresorcinols, and at 25 h significant amounts of metabolites were still retained in the body, suggesting that even a spot urine sample may be sufficient to indicate whether or not wholegrain wheat or rye is a daily dietary component. These results support the use of urinary DHPPA and DHBA as biomarkers of wholegrain wheat and rye and enable new potential for studying the association between wholegrain intake and diseases, even in the absence of dietary data.
Päivi P Söderholm; Johan E Lundin; Anja H Koskela; Matti J Tikkanen; Herman C Adlercreutz
Related Documents :
19819118 - Consumption of diets with different type of fat influences triacylglycerols-rich lipopr...
17425628 - Effect of timing of dosing in relation to food intake on the pharmacokinetics of esomep...
10722778 - Effects of training status on the metabolic responses to high carbohydrate and high fat...
14526928 - Intake and excretion of 99tc in a common sea alga, hijiki (hizikia fusiforme), as inges...
10082778 - Calcium does not inhibit iron absorption or alter iron status in infant piglets adapted...
8007738 - Acat inhibitors as antiatherosclerotic agents: compounds and mechanisms.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-12
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Folkhälsan Research Centre, Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Perineal care.
Next Document:  The nutrition transition in the Republic of Ireland: trends in energy and nutrient supply from 1961 ...