| Pharmacokinetics after intravenous administration of flunixin meglumine in budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). | |
| | |
MedLine Citation:
|
PMID: 23276097 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective-To investigate the disposition kinetics of flunixin meglumine when administered IV to budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). Design-Prospective cohort study. Animals-8 adult Patagonian conures and 24 adult budgerigars. Procedures-Injectable flunixin meglumine (50 mg/mL) was diluted to 10 and 1. 0 mg/mL and administered IV at a dose of 5.0 mg/kg (2.3 mg/lb) to Patagonian conures and budgerigars, respectively. Results-In budgerigars, the elimination half-life was 0.72 hours and the mean residence time was 0.73 hours. In Patagonian conures, the elimination half-life was 0.91 hours and the mean residence time was 1.20 hours. The concentration of flunixin was below the assay's limit of quantification (0.5 μg/mL) at 3 and 6 hours in budgerigars and Patagonian conures, respectively. A single budgerigar developed adverse effects (lethargy and signs of depression) for approximately 15 minutes following drug administration. Conclusions and Clinical Relevance-The half-life of flunixin in Patagonian conures and budgerigars was short following IV administration; however, results of this study suggested that IV administration of injectable flunixin meglumine at 5.0 mg/kg resulted in plasma concentrations that could potentially be anti-inflammatory and analgesic in budgerigars and Patagonian conures. |
| | |
Authors:
|
Jeffrey M B Musser; J Jill Heatley; David N Phalen |
Related Documents
:
|
18464057 - Toxicological comparisons of three styles of a commercial u.s. cigarette (marlboro with... 1483037 - Dose-response relationships of alimentary ptcl2 and ptcl4 in growing rats. 23436267 - Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine k... 18844727 - Dose-response effect of ferulic acid against nicotine-induced tissue damage and altered... 9150417 - Effect of route and frequency of administration of apomorphine on growth hormone releas... 11406737 - Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American Veterinary Medical Association Volume: 242 ISSN: 1943-569X ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
|
Languages: eng Pagination: 205-8 Citation Subset: IM |
Affiliation:
|
Schubot Exotic Bird Health Center, College of Veterinary Medicine, Texas A&M University, College Station, TX, 77843., Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX, 77843. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of mepivacaine in an infraorbital nerve block on minimum alveolar concentration of isoflurane...
Next Document: Prevalence of and exposure factors for seropositivity to H3N8 canine influenza virus in dogs with in...