Document Detail


Pharmacokinetics and tolerability of single-dose daptomycin in young infants.
MedLine Citation:
PMID:  22627869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Daptomycin is approved for the treatment of complicated skin and skin-structure infections and Staphylococcus aureus bacteremia. We sought to characterize daptomycin single-dose pharmacokinetics and tolerability in young infants.
METHODS: Subjects < 120 days of age with suspected systemic infections were eligible for inclusion. Each subject was given a single 6 mg/kg intravenous dose of daptomycin. An average of 4 postdose concentrations per infant was obtained.
RESULTS: Data from 20 infants are presented. Median gestational age at birth and postnatal age were 32 weeks (range: 23, 40) and 3 days (1, 85), respectively. The median area under the concentration curve at 24 hours, volume of distribution, total body clearance and half-life of daptomycin were 262.4 mg×h/L (166.7, 340.2), 0.21 L/kg (0.11, 0.34), 0.021 L/h/kg (0.016, 0.034) and 6.2 hours (3.7, 9.0), respectively. No adverse events related to daptomycin were observed, including changes in creatine phosphokinase concentrations.
CONCLUSIONS: Daptomycin clearance in young infants was similar to that in children 2-6 years of age and higher than that observed in adolescents and adults.
Authors:
Michael Cohen-Wolkowiez; Kevin M Watt; Christoph P Hornik; Daniel K Benjamin; P Brian Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  31     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2013-01-21     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  935-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Duke University Medical Center, and †Duke Clinical Research Institute, Durham, NC 27715, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / adverse effects*,  pharmacokinetics*
Bacteremia / drug therapy,  metabolism*
Daptomycin / adverse effects*,  pharmacokinetics*
Female
Humans
Infant, Newborn
Male
Prospective Studies
Staphylococcal Skin Infections / drug therapy,  metabolism*
Grant Support
ID/Acronym/Agency:
1K23HD064814-01/HD/NICHD NIH HHS; 1K24HD058735-01/HD/NICHD NIH HHS; 1R01FD003519-01/FD/FDA HHS; 1R01HD057956-02/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; 1U10-HD45962-06/HD/NICHD NIH HHS; 5T32HD043029-09/HD/NICHD NIH HHS; K23 HD060040/HD/NICHD NIH HHS; K23HD060040-01/HD/NICHD NIH HHS; K24 HD058735/HD/NICHD NIH HHS; L40 HD069892/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 103060-53-3/Daptomycin
Comments/Corrections

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