| Pharmacokinetics of extended-release dipyridamole following administration through a gastrostomy tube: an open-label, case-control, two-centre study. | |
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MedLine Citation:
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PMID: 20433215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Many stroke survivors have severe dysphagia and are unable to take antithrombotic medications orally. OBJECTIVE: To evaluate whether dipyridamole concentrations achieved in the plasma of patients taking an extended-release formulation of the medication through a gastrostomy tube (G-tube) are therapeutic and similar to those achieved in the plasma of patients who receive the drug orally. METHODS: This was an open-label, case-control, two-centre study conducted in two academic centres in a metropolitan area. Patients included were those admitted following an acute cerebral infarction, with an indication for antiplatelet therapy for secondary prevention. Twelve patients with severe dysphagia requiring G-tube placement were cases, and 12 patients who were able to swallow safely served as controls. The components of Aggrenox (extended-release dipyridamole/aspirin [acetylsalicylic acid]), suspended in water, were administered twice daily for 5 days through the G-tube. The 12 control patients without dysphagia took the medication orally. Dipyridamole plasma concentrations were compared between the groups at three different timepoints on the fifth day: 2, 6 and 12 hours after administration. The main outcome measure was dipyridamole plasma concentrations on day 5 at all three timepoints. RESULTS: No significant difference in dipyridamole plasma concentrations between the groups was found at 2 hours (p = 0.18), 6 hours (p = 0.92) or 12 hours (p = 0.69). CONCLUSION: Dipyridamole plasma concentrations obtained following administration of extended-release dipyridamole through a G-tube in dysphagic patients achieved similar therapeutic levels to those obtained in patients taking the medication orally. |
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Authors:
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Leonardo M Batista; David Crandell; Fabricio O Lima; David M Greer |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical drug investigation Volume: 30 ISSN: 1173-2563 ISO Abbreviation: Clin Drug Investig Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504817 Medline TA: Clin Drug Investig Country: New Zealand |
Other Details:
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Languages: eng Pagination: 483-8 Citation Subset: IM |
Affiliation:
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J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aggrecans / administration & dosage* Case-Control Studies Cerebral Infarction / complications*, drug therapy Deglutition Disorders / complications, etiology Delayed-Action Preparations Dipyridamole / administration & dosage, pharmacokinetics* Female Gastrostomy* Humans Male Middle Aged Platelet Aggregation Inhibitors / administration & dosage, pharmacokinetics* Severity of Illness Index Stroke / prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Aggrecans; 0/Delayed-Action Preparations; 0/Platelet Aggregation Inhibitors; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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