| Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula. | |
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MedLine Citation:
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PMID: 20184950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The present study is designed to elucidate disparities in the clinical efficacy of two ZZW varieties based on the pharmacokinetics of naringenin and hesperetin. MEHTOD: After oral administration of ZZWs, blood sample was collected from healthy volunteers at designed time points. Naringenin and hesperetin were detected in plasma by RP-HPLC, pharmacokinetic parameters were processed using mode-independent methods with WINNONLIN. RESULTS: After oral administration of BZZW, both naringenin and hesperetin were detected in plasma, and demonstrated similar pharmacokinetic parameters. Ka was 0.384+/-0.165 and 0.401+/-0.159, T(1/2(ke))(h) was 5.491+/-3.926 and 5.824+/-3.067, the AUC (mg/Lh) was 34.886+/-22.199 and 39.407+/-19.535 for naringenin and hesperetin, respectively. However, in the case of RZZW, only hesperetin was found in plasma, but the pharmacokinetic properties for hesperetin in RZZW was different from that in BZZW. T(max) for hesperetin in RZZW is about 8.515h, and its C(max) is much larger than that of BZZW. Moreover, it was eliminated slowly as it possessed a much larger AUC value. CONCLUSION: The distinct therapeutic orientations of the Chinese medical formula ZZWs with different Fructus Citrus Immaturus could be elucidated based on the pharmacokinetic parameters of constituents after oral administration. |
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Authors:
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Hongxin Cao; Xi Chen; Hui Sun; Tetsuro Sakurai; Jue Zhou; Wenjun Sun; Haitao Lv; Xijun Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-23 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 128 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 606-10 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Harbin 150040, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Animals Area Under Curve Asian Continental Ancestry Group Chromatography, High Pressure Liquid / methods Citrus / chemistry* Citrus sinensis / chemistry* Cricetinae Cricetulus Flavanones Hesperidin Humans Male Wiskott-Aldrich Syndrome Wiskott-Aldrich Syndrome Protein |
| Chemical | |
Reg. No./Substance:
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0/Flavanones; 0/Wiskott-Aldrich Syndrome Protein; 480-41-1/naringenin; 520-26-3/Hesperidin; 520-33-2/hesperetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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