Document Detail


Pharmacokinetics of amphotericin B colloidal dispersion in critically ill patients with cholestatic liver disease.
MedLine Citation:
PMID:  22850517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of lipid-bound and liberated amphotericin B (AMB) was assessed in 11 critically ill patients with cholestatic liver disease (CSLD) and in 9 subjects with normal liver function treated with AMB colloidal dispersion (ABCD). Exposure to lipid-bound AMB was higher in patients with CSLD. Levels of liberated AMB were elevated by CSLD only after the first dose, whereas its pharmacokinetics was unaffected at steady state. The standard dosage of ABCD is probably adequate for patients with CSLD.
Authors:
Stefan Weiler; Elisabeth Überlacher; Julia Schöfmann; Eva Stienecke; Stefan Dunzendorfer; Michael Joannidis; Romuald Bellmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-30
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-13     Completed Date:  2013-02-01     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5414-8     Citation Subset:  IM    
Affiliation:
Clinical Pharmacokinetics Unit, Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Amphotericin B / blood,  pharmacokinetics*
Antifungal Agents / blood,  pharmacokinetics*
Child
Colloids
Critical Illness*
Female
Humans
Liver Diseases / blood*,  drug therapy
Male
Middle Aged
Young Adult
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Colloids; 1397-89-3/Amphotericin B
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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