Document Detail

Pharmacokinetics of 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo- [ 2,6-endo] dec-8-en-3-one in the rat
MedLine Citation:
PMID:  3382460     Owner:  NLM     Status:  MEDLINE    
Pharmacokinetics of 4-Oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo- [ 2,6endo]dec-8-en-3one in the Rat The pharmacokinetics of 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo- [ 2,6endo]dec-8-en-3one (Lu 253) were investigated after oral application in male Wistar rats. The compound is extensively absorbed and mainly renally eliminated. Within 60 h, 63% of the activity is recovered in urine and faeces. After 12 h 27% of the activity is eliminated (application in polyethylene glycol). The highest total concentration of the activity in the plasma is found after 2 h, the highest of the unchanged drug is found after 1 h. The half-life is 2.9 h. The concentration in plasma is mathematically characterized by the parameters of a two-compartiment model and also independent of a model. Lu 253 is distributed in the whole organism, a maximum of activity is achieved 2 h after application. By whole-body autoradiography the entrance of the compound into liquor and an enduring accumulation in the frontal cavity is detected.
R Neidlein; H P Deigner
Publication Detail:
Type:  English Abstract; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  38     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-07-20     Completed Date:  1988-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  359-63     Citation Subset:  IM    
Pharmazeutisch-Chemischen Institut, Universität Heidelberg.
Vernacular Title:
Pharmakokinetik von 4-Oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo- [ 2,6endo]dec-8-en-3on an der Ratte.
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MeSH Terms
Analgesics / metabolism,  pharmacokinetics*
Bile / metabolism
Carbamates / metabolism,  pharmacokinetics*
Hydrogen-Ion Concentration
Protein Binding
Rats, Inbred Strains
Tissue Distribution
Reg. No./Substance:
0/Analgesics; 0/Carbamates; 0/LU 253

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