| Pharmacokinetics of 250 μg anti-D IgG in the third trimester of pregnancy: an observational study. | |
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MedLine Citation:
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PMID: 22352370 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective. We present a pharmacokinetic study evaluating a single intramuscular dose of 250 μg anti-D immunoglobulin in the third trimester of pregnancy. The aim of the study was to determine the kinetic profile and duration of detectable levels of anti-D. Design. Prospective observational study. Setting. Antenatal outpatient clinic. Population. Healthy RhD negative pregnant women with an RHD positive fetus. Material and methods. Serial plasma anti-D quantitations following antenatal administration of anti-D immunoglobulin were performed using flow cytometry. Kinetic profiles for anti-D levels were generated from the concentration values at pre-set sampling timepoints. The half-lives were calculated by linear regression analysis. Main outcome measures. Time versus concentration profile, half-life, anti-D concentration ≥ 1 ng/mL close to term. Results. Maximum plasma concentration of anti-D was usually seen at 3-10 days post-injection with a median value of 25 ng/mL. The half-life varied between individuals with a median of 23 days. We found detectable levels of anti-D IgG within two weeks of parturition in 11/12 women (C(last) ). Conclusion. The preparation of anti-D immunoglobulin used in the present study, if administrated in pregnancy week 28-30, is associated with detectable levels of anti-D in most women at the time of delivery. Although the halftime is 23 days it is an open question if all mothers have adequate anti-D concentrations at term. Alternative strategies may be evaluated in the future with repeated administration of antenatal prophylaxis at term rather than conventional postpartum administration of anti D. |
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Authors:
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Eleonor Tiblad; Agneta Wikman; Anders Rane; Yvonne Jansson; Magnus Westgren |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-21 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: - ISSN: 1600-0412 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors AOGS© 2012 Nordic Federation of Societies of Obstetrics and Gynecology. |
Affiliation:
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Department of Obstetrics and Gynecology, Department of Immunology and Transfusion Medicine, and Department of Clinical Pharmacology, Karolinska University Hospital and Karolinska Institute, Stockholm. Sweden. |
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