Document Detail


Pharmacokinetic and therapeutic trial of sultamicillin in acute sinusitis.
MedLine Citation:
PMID:  3002247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sultamicillin, an antibiotic combining ampicillin and the beta-lactamase inhibitor sulbactam, was administered to 13 patients diagnosed as having acute sinusitis. Specimens from sinus were obtained for all 13 patients by transantral puncture. Pharmacokinetics, bacteriology, and therapeutic efficacy were assessed. Eighty-five percent (11 of 13) were cured; two treatment failures were subsequently shown to have chronic (rather than acute) sinusitis during surgical exploration. Diarrhea was frequently encountered, and Clostridium difficile-associated enteritis was documented for one patient. Beta-lactamase-producing organisms were not encountered in this study; however, this study provides impetus for further controlled clinical trials.
Authors:
S Jones; V L Yu; J T Johnson; R L Wagner; H K Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  28     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-20     Completed Date:  1986-02-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amoxicillin / blood,  metabolism
Ampicillin / adverse effects,  metabolism,  therapeutic use*
Bacterial Proteins*
Bacterial Toxins / isolation & purification
Cefaclor / blood,  metabolism
Diarrhea / chemically induced
Drug Combinations / adverse effects,  metabolism,  therapeutic use
Humans
Maxillary Sinus / metabolism,  microbiology
Microbial Sensitivity Tests
Penicillanic Acid / adverse effects,  metabolism,  therapeutic use*
Sinusitis / drug therapy*,  microbiology
Sulbactam
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Drug Combinations; 0/toxB protein, Clostridium difficile; 26787-78-0/Amoxicillin; 53994-73-3/Cefaclor; 68373-14-8/Sulbactam; 69-53-4/Ampicillin; 76497-13-7/sultamicillin; 87-53-6/Penicillanic Acid
Comments/Corrections

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