| Pharmacokinetic study of apomorphine-induced stereotypy in food deprived rats. | |
| | |
MedLine Citation:
|
PMID: 7195038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between the effect of food deprivation on apomorphine-induced stereotypy and the plasma apomorphine concentration in rats was studied. Male Wistar rats, allowed to have free access to food and water on deprived of food for 48 hr, were injected subcutaneously with apomorphine hydrochloride (10 mg/kg). Food deprivation was liable to potentiate the apomorphine-induced stereotypy in the early stage after dosing. Higher plasma apomorphine concentrations were found in the food deprived rats at this observation period. The potentiation of apomorphine-induced stereotypy following food deprivation can in part be explained by the pharmacokinetics changes. The exact mechanism of the effect of food deprivation on apomorphine kinetics is not clear at present. |
| | |
Authors:
|
H Watanabe; S Nakano; N Ogawa |
Related Documents
:
|
19144218 - Food deprivation is integral to the 'hand to mouth' existence of homeless youths in tor... 10234028 - Differential regulation of the expression of corticotropin-releasing factor receptor ty... 6844438 - Plasma catecholamines in fasted and sucrose supplemented rats. 18405418 - A role for dopamine d1-like receptors in acute food deprivation-induced reinstatement o... 16673008 - Eosinophilic esophagitis: an overlooked entity in chronic dysphagia. 8239718 - Protection afforded greenhouse pesticide applicators by coveralls: a field test. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 14 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1981 Apr |
Date Detail:
|
Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 493-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apomorphine / blood*, pharmacology Food Deprivation* Humans Kinetics Male Rats Stereotyped Behavior / drug effects* |
| Chemical | |
Reg. No./Substance:
|
58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Subchronic treatment with the tricyclic antidepressant DMI increases isolation-induced fighting in r...
Next Document: Handling-induced seizures and rotational behavior in th Mongolian gerbil.