| Pharmacokinetic studies of theophylline in dogs. | |
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MedLine Citation:
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PMID: 7349323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of theophylline were investigated in dogs following intravenous, single oral, and multiple oral doses of aminophylline. Mean half-life (t1/2) of theophylline following single intravenous administration was 5.7 h and the apparent specific volume of distribution (V'd area) was 0.82 litre/kg. The bioavailability of theophylline was high (91%) following oral administration of aminophylline tablets and the absorption half-life (t1/2ab) was 0.4 h. Theophylline plasma concentrations observed following repeated oral administration of aminophylline tablets were somewhat greater than predicted. This suggests that theophylline plasma concentrations should be monitored and the dosage regimen individually adjusted in critically ill animals. |
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Authors:
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B C McKiernan; C A Neff-Davis; G D Koritz; L E Davis; D R Pheris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary pharmacology and therapeutics Volume: 4 ISSN: 0140-7783 ISO Abbreviation: J. Vet. Pharmacol. Ther. Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1983-03-11 Completed Date: 1983-03-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910920 Medline TA: J Vet Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 103-10 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Availability Dogs / metabolism* Half-Life Injections, Intravenous Kinetics Tablets Theophylline / administration & dosage, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tablets; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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