Document Detail

Pharmacokinetic and pharmacodynamic studies of piretanide in rabbits. I. Effect of different hydrated conditions.
MedLine Citation:
PMID:  3694429     Owner:  NLM     Status:  MEDLINE    
The pharmacokinetics and pharmacodynamics of piretanide in rabbits were investigated. After intravenous administration, the plasma concentrations and the urinary excretion rates of piretanide, as well as the pharmacologic effects, were measured under two different hydrated conditions. In one experiment, the amount of the body fluid which was lost during diuresis was replaced by infusing Ringer's solution at exactly the same rate with the urine flow rate (treatment I). In another experiment, no compensatory infusion was made (treatment II). There was no appreciable difference between treatment I and II, as far as the plasma concentrations and urinary excretion rate were concerned. In spite of the similarities in the pharmacokinetic properties, the pharmacologic effects of piretanide were influenced considerably by the hydrated conditions of the body. The diuretic effect expressed as the excretion rate of the sum of urinary sodium and potassium was plotted against the corresponding urinary excretion rate of unchanged piretanide. The shape of the each graph showed a similar sigmoid like curve; however, the curve in treatment I was significantly shifted to the right compared to that in treatment II. This fact indicated that the pharmacologic effect of piretanide seemed to be modified by the contents of water and electrolytes in the body. The plasma concentrations and urinary excretion of piretanide were reasonably described by a linear three compartment open model.(ABSTRACT TRUNCATED AT 250 WORDS)
W Lu; M Endoh; K Katayama; M Kakemi; T Koizumi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  10     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  356-63     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Diuretics / pharmacokinetics*,  pharmacology
Glomerular Filtration Rate
Injections, Intravenous
Potassium / blood,  urine
Sodium / blood,  urine
Sulfonamides / pharmacokinetics*,  pharmacology
Urodynamics / drug effects
Reg. No./Substance:
0/Diuretics; 0/Sulfonamides; 55837-27-9/piretanide; 7440-09-7/Potassium; 7440-23-5/Sodium

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