| Pharmacokinetic-pharmacodynamic modelling for captopril in healthy anaesthetized piglets. | |
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MedLine Citation:
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PMID: 8830975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of the angiotensin converting enzyme inhibitor, captopril, specially in children, has been empirical. This is because the relationship between the pharmacokinetics and pharmacodynamics of captopril has not been clearly defined. It is not usually feasible to obtain the serial kinetic-dynamic data necessary to study this relationship in infants. The piglet was therefore investigated as an animal model in which to study the relationship between the kinetics and dynamics of captopril. The standard pharmacokinetic parameters for captopril in healthy anaesthetized piglets were found to be within the range reported for humans. ClTB was estimated to be 1.42 +/- 0.33 L h-1 kg(-1); t1/2 was 0.44 +/- 0.08 h; Vdss was calculated to be 0.64 +/- 0.13 L kg(-1); t1/2 and AUC0-infinity was estimated to be 145 +/- 27 ng h mL(-1). The observed haemodynamic response was qualitatively similar to that in humans. Aortic pressure was reduced by 42 +/- 18%; heart rate was reduced by 21 +/- 11%. A parametric pharmacokinetic (two-compartment)-pharmacodynamic (linear) model has been established to describe plasma captopril concentration and aortic pressure relationship. Based on the observed results, the piglet was considered to be a viable model for our purpose. |
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Authors:
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C M Pereira; Y K Tam; J Y Coe; P M Olley; R L Collins-Nakai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 17 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-12-10 Completed Date: 1996-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 365-72 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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administration & dosage,
blood,
pharmacokinetics*,
pharmacology Animals Animals, Newborn Blood Pressure / drug effects* Captopril / administration & dosage, blood, pharmacokinetics*, pharmacology Chromatography, High Pressure Liquid Half-Life Heart Atria / drug effects Heart Ventricles / drug effects Myocardial Contraction / drug effects Pulmonary Artery / metabolism Software Swine |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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