Document Detail


Pharmacokinetic-pharmacodynamic modelling for captopril in healthy anaesthetized piglets.
MedLine Citation:
PMID:  8830975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of the angiotensin converting enzyme inhibitor, captopril, specially in children, has been empirical. This is because the relationship between the pharmacokinetics and pharmacodynamics of captopril has not been clearly defined. It is not usually feasible to obtain the serial kinetic-dynamic data necessary to study this relationship in infants. The piglet was therefore investigated as an animal model in which to study the relationship between the kinetics and dynamics of captopril. The standard pharmacokinetic parameters for captopril in healthy anaesthetized piglets were found to be within the range reported for humans. ClTB was estimated to be 1.42 +/- 0.33 L h-1 kg(-1); t1/2 was 0.44 +/- 0.08 h; Vdss was calculated to be 0.64 +/- 0.13 L kg(-1); t1/2 and AUC0-infinity was estimated to be 145 +/- 27 ng h mL(-1). The observed haemodynamic response was qualitatively similar to that in humans. Aortic pressure was reduced by 42 +/- 18%; heart rate was reduced by 21 +/- 11%. A parametric pharmacokinetic (two-compartment)-pharmacodynamic (linear) model has been established to describe plasma captopril concentration and aortic pressure relationship. Based on the observed results, the piglet was considered to be a viable model for our purpose.
Authors:
C M Pereira; Y K Tam; J Y Coe; P M Olley; R L Collins-Nakai
Related Documents :
7026255 - Antihypertensive and hormonal effects of single oral doses of captopril and nifedipine ...
11836545 - Normal erythrocyte calpain i activity on membrane proteins under near-physiological con...
3038405 - Tissue converting enzyme inhibition and cardiovascular effects of converting enzyme inh...
18605985 - Rna interference targeting the ace gene reduced blood pressure and improved myocardial ...
804465 - Rate factors in development of the high-pressure neurological syndrome.
23219785 - Assessment of differenced center of pressure time series improves detection of age-rela...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  17     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  blood,  pharmacokinetics*,  pharmacology
Animals
Animals, Newborn
Blood Pressure / drug effects*
Captopril / administration & dosage,  blood,  pharmacokinetics*,  pharmacology
Chromatography, High Pressure Liquid
Half-Life
Heart Atria / drug effects
Heart Ventricles / drug effects
Myocardial Contraction / drug effects
Pulmonary Artery / metabolism
Software
Swine
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mutagenic activity of various dentine bonding agents.
Next Document:  Comparison of pharmacokinetics of M1, M2, M3, and M4 after intravenous administration of DA-125 or M...