| Pharmacokinetic modeling of dynamic contrast-enhanced MRI of the hand and wrist in rheumatoid arthritis and the response to anti-tumor necrosis factor-alpha therapy. | |
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MedLine Citation:
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PMID: 17763341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced MRI (DCE-MRI) of the hand and wrist was performed in 11 patients with rheumatoid arthritis twice before and once 2 weeks after treatment with anti-tumor necrosis factor (TNF)-alpha therapy. A rapid, T1-weighted 3D spoiled gradient echo (SPGR) sequence was used for the dynamic imaging. T1 estimation was performed using similar images obtained at different flip angles. The relative radiofrequency field was estimated from the known T1 of the periarticular fatty marrow. The arterial input function (AIF) was measured at each examination, and normalized to the expected plasma concentration to reduce partial volume effects. Synovial enhancement was modeled to yield values for Ktrans, ve, and vp. Ktrans and ve showed good reproducibility. There was a significant decrease of about 20% in Ktrans after 2 weeks of treatment. This study demonstrates the potential of DCE-MRI and pharmacokinetic modeling to study early changes in inflammatory activity in rheumatoid arthritis following treatment. |
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Authors:
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Richard J Hodgson; Sylvia Connolly; Theresa Barnes; Brian Eyes; Robert S D Campbell; Robert Moots |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 58 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-05 Completed Date: 2007-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 482-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Magnetic Resonance and Image Analysis Research Centre, and School of Clinical Sciences, University of Liverpool, Liverpool, and Whiston Hospital, Merseyside, UK. RichardHodgson@btinternet.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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therapeutic use* Arthritis, Rheumatoid / drug therapy, pathology* Bone Marrow / pathology Contrast Media* Gadolinium / diagnostic use Heterocyclic Compounds / diagnostic use Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods Imaging, Three-Dimensional / methods Magnetic Resonance Imaging / methods* Metacarpophalangeal Joint / drug effects, pathology* Models, Biological Organometallic Compounds / diagnostic use Reproducibility of Results Synovial Membrane / drug effects, pathology Synovitis / drug therapy, pathology Treatment Outcome Tumor Necrosis Factor-alpha / antagonists & inhibitors* Wrist Joint / drug effects, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0/Tumor Necrosis Factor-alpha; 7440-54-2/Gadolinium; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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