| Pharmacokinetic modeling of Gd-DTPA extravasation in brain tumors. | |
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MedLine Citation:
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PMID: 12352165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: The endothelial permeability of brain tumors affecting the blood-brain barrier can be quantified using dynamic contrast enhanced MR imaging. MATERIALS AND METHODS: The dynamics of contrast medium (CM) exchange was investigated in 31 brain tumors (intra- and extra-axial) by fast repeated T1-weighted imaging in order to determine the exchange rates and saturation concentrations. RESULTS: The analysis of CM exchange reveals two different transport processes from the blood into two separate interstitial subcompartments for intra- and extra-axial tumors, a rapid one with a transfer constant of 1/ =7.0 seconds and a slow one with 1/ =133.7 seconds. Highly significant differences exhibit gliomas and meningiomas with respect to the saturation concentrations of fast and slowly enhancing compartments. CONCLUSIONS: The fast component is probably caused by extravasation into viable tissue (enhanced in meningiomas) while the slow one probably reflects increased diffusion distances into poorly perfused tissue such as necrotic areas in glioblastomas. |
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Authors:
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Lutz Ludemann; Reinhard Wurm; Claus Zimmer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 37 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-27 Completed Date: 2002-12-19 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 562-70 Citation Subset: IM |
Affiliation:
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Department of Radiology and Neuroradiology, CCM Universitätsklinikum Charité, Berlin, Germany. lutz.luedemann@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood-Brain Barrier Brain Neoplasms / blood supply, diagnosis*, pathology Cerebrovascular Circulation Child Contrast Media / pharmacokinetics* Extravasation of Diagnostic and Therapeutic Materials* Female Gadolinium DTPA / diagnostic use, pharmacokinetics* Humans Magnetic Resonance Imaging* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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