| Pharmacokinetic model for procaine in humans during and following intravenous infusion. | |
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MedLine Citation:
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PMID: 480155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multicompartment pharmacokinetic model is presented to describe procaine distribution in humans during and following intravenous infusion. The model, based on a general perfusion model, relates individual characteristics such as sex, age, weight, height, infusion rate and duration, and hematocrit to general parameters such as drug metabolism, protein binding, ion-trapping effects, and tissue-plasma distribution coefficients to provide an individualized distribution prediction. Experimentally observed kinetics of blood procaine levels collected during intravenous procaine infusion as an adjunct to surgical anesthesia and blood lidocaine levels obtained from the literature compared very well with the model simulation. |
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Authors:
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R H Smith; D H Hunt; A B Seifen; A Ferrari; D S Thompson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 68 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-11-28 Completed Date: 1979-11-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1016-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Infusions, Parenteral Kinetics Models, Biological Procaine / administration & dosage, blood, metabolism*, pharmacology Time Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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59-46-1/Procaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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