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Pharmacokinetic model of myocardial (99m)Tc-sestamibi washout.
MedLine Citation:
PMID:  23344692     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Technetium-99m sestamibi ((99m)Tc-MIBI) scintigraphy has been reported to be a functional imaging tool for in vivo detection of mitochondrial dysfunction in myocardium and multidrug resistance-associated protein expression in tumors. The purpose of this study was to propose a clinically applicable pharmacokinetic model with metabolic equilibrium of (99m)Tc-MIBI and to evaluate the accuracy of the model. METHODS: For this study, eight healthy men received (99m)Tc-MIBI scintigraphy. The planar images were obtained at 0.25, 0.5, 1, 2, 3, 4, 5, and 6 h after (99m)Tc-MIBI injection. The measured time series (99m)Tc-MIBI counts were fitted to our model by nonlinear regression analysis. The predictive performance of the model was determined by comparing the residuals between measured and predicted values. RESULTS: We obtained a good regression by fitting data from 0.25 to 6 h after (99m)Tc-MIBI injection, with excellent correlation between measured and predicted (99m)Tc-MIBI counts (R (2) = 0.9792) and a slope near unity. The 95 % confidence interval of the mean prediction error included 0, which means that the prediction was not significantly biased. The precision of the prediction was also excellent. CONCLUSIONS: Our model shows good predictive capacity, with favorable bias and accuracy. By comparing the predictive values of this model with measured values, mitochondrial (99m)Tc-MIBI washout can be quantified. (99m)Tc-MIBI washout rates are reported to be a promising method for evaluating cardiac function in patients with cardiac diseases and P-glycoprotein expression in tumor cells. Therefore, this quantification could be useful for mitochondrial functional imaging, especially in patients with cardiac diseases or tumors.
Authors:
Tsubasa Watanabe; Hajime Monzen; Masatake Hara; Takashi Mizowaki; Masahiro Hiraoka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  -     ISSN:  1864-6433     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan, tsuwata@kuhp.kyoto-u.ac.jp.
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