| Pharmacokinetic interactions between warfarin and kangen-karyu, a Chinese traditional herbal medicine, and their synergistic action. | |
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MedLine Citation:
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PMID: 12169403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kangen-Karyu (KGK), containing six herbs, is a formula created under the theory of Chinese traditional medicine (CTM) to invigorate the 'blood' and dispel 'blood stasis', which arises from poor blood circulation. The present study was conducted to evaluate the interactions between KGK and warfarin. Warfarin was administered orally or intravenously to KGK-treated rats, and plasma warfarin concentration and prothrombin time were measured. Although KGK did not influence the absorption or serum protein binding of warfarin, KGK significantly suppressed the metabolism and elimination of warfarin. This interaction depends on the dosage of KGK, and ten times the amount of the human daily dose of KGK did not exhibit pharmacokinetic interaction with warfarin, suggesting that KGK did not influence the effect of warfarin unless the daily dose was strictly maintained. Warfarin alone significantly prolonged mice tail-bleeding time, which was further prolonged significantly by KGK at a dose that did not exhibit pharmacokinetic interactions with warfarin, suggesting that KGK and warfarin might synergistically prevent thrombosis, and that combined use of these drugs could be therapeutically valuable. When physicians or pharmacists utilize combined therapy using warfarin and KGK, they must make a careful effort to check the coagulative status and regulate the dosage of each drug. |
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Authors:
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Toshiaki Makino; Hannosuke Wakushima; Takuya Okamoto; Yasuhiro Okukubo; Yoshiharu Deguchi; Yoshihiro Kano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 82 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-08-09 Completed Date: 2003-04-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 35-40 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
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Department of Kampo Medicinal Science, Hokkaido College of Pharmacy, Katsuraoka, Otaru 047-0264, Japan. makino@hokuyakudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anticoagulants / administration & dosage, blood, pharmacokinetics* Chromatography, High Pressure Liquid Drug Synergism Drugs, Chinese Herbal / administration & dosage, pharmacokinetics* Herb-Drug Interactions Injections, Intravenous Male Mice Prothrombin Time Rats Rats, Wistar Warfarin / administration & dosage, blood, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Drugs, Chinese Herbal; 0/Kangen-karyu; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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