| Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats. | |
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MedLine Citation:
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PMID: 20039777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telithromycin and metformin have been reported to be commonly metabolized via hepatic CYP3A1/2 in rats. Community-acquired respiratory tract infection was reported to be frequent in patients with diabetes mellitus. Compared with controls, hepatic CYP3A1/2 was reported to be increased in male rats with diabetes mellitus induced by streptozotocin (DMIS rats). After the intravenous administration of both drugs together to male DMIS rats, the time-averaged non-renal clearance (CL(NR)) of metformin was significantly slower (by 33.1%; 10.3 versus 15.4 ml min(-1) kg(-1)) than metformin alone due to the inhibition of hepatic metabolism of metformin by telithromycin via CYP3A1/2. After the oral administration of both drugs together, the total area under the plasma concentration-time curve (AUC) of metformin was comparable possibly due to the increased intestinal metabolism of metformin by telithromycin. |
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Authors:
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J H Lee; H E Kang; M G Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 40 ISSN: 1366-5928 ISO Abbreviation: Xenobiotica Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-11 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: England |
Other Details:
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Languages: eng Pagination: 217-24 Citation Subset: IM |
Affiliation:
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College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea. leemg@snu.ac.kr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Blood Proteins / metabolism Diabetes Mellitus / drug therapy* Dialysis Drug Interactions Injections, Intravenous Intestines / metabolism Ketolides / administration & dosage, blood, pharmacokinetics*, therapeutic use* Male Metformin / administration & dosage, blood, pharmacokinetics*, therapeutic use* Microsomes, Liver / metabolism Protein Binding Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Ketolides; 0/telithromycin; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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