| Pharmacokinetic interaction between methotrexate and chloral hydrate. | |
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MedLine Citation:
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PMID: 23151940 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. |
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Authors:
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Kim Dao; Anton Ivanyuk; Thierry Buclin; Maja Beck-Popovic; Manuel Diezi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: - ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Division of Clinical Pharmacology, Biomedicine, Department of Laboratories, CHUV, Lausanne, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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