Document Detail

Pharmacokinetic individualisation of zidovudine therapy. Current state of pharmacokinetic-pharmacodynamic relationships.
MedLine Citation:
PMID:  8983861     Owner:  NLM     Status:  MEDLINE    
Zidovudine is the cornerstone of current antiretroviral treatment of human immunodeficiency virus (HIV) infection. Its use, however, frequently leads to adverse reactions, including myelosuppression. Zidovudine pharmacokinetics show large interindividual variation with indications of pharmacokinetic-pharmacodynamic relationships, but a clear therapeutic window has not yet been defined. Individualisation of zidovudine therapy with monitoring of drug concentrations might be desirable. This review considers (intracellular) monitoring of zidovudine and anabolites for individualisation of zidovudine therapy and the achievements in describing pharmacokinetic-pharmacodynamic relationships so far.
R M Hoetelmans; D M Burger; P L Meenhorst; J H Beijnen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  30     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-01-07     Completed Date:  1997-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  314-27     Citation Subset:  IM; X    
Department of Pharmacy, Slotervaart Hospital, Amsterdam, Netherlands.
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MeSH Terms
Antiviral Agents / pharmacokinetics*,  pharmacology
HIV Infections / metabolism*
Prodrugs / pharmacokinetics*,  pharmacology
Zidovudine / analogs & derivatives,  pharmacokinetics*,  pharmacology
Reg. No./Substance:
0/Antiviral Agents; 0/Prodrugs; 30516-87-1/Zidovudine

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